It is possible to drill acrylic with regular metal drill bits.
Drilling holes in acrylic sheets.
This barrier will help avoid cracking of the sheet when drilling the final hole.
This barrier may be a piece of wood that you would not mind drilling into.
Unlike drilling a hole through metal or wood plexiglass sheets call for extra caution.
The tip must scrape the acrylic not gouge it.
However the likelihood of melting chipping cracking or breaking the acrylic is much higher.
Drilling holes in acrylic requires the use of a drill bit specially designed for use with plastics.
Standard metal drill bits will work but without extensive modification the metal drill bit will crack and chip the brittle acrylic sheet.
If this is not the case the drill is too slow.
Press only lightly on the drill the drill must sink itself through the material.
Drilling holes in acrylic sheet place the drill perpendicular to the acrylic sheet and set the drill to medium speed immediately.
Before you start drilling you ought to place a barrier below the plexiglass.
The cutter bit must also be modified to accommodate the material properties of acrylic.